HolisticA
Root-Cause Medicine
Fatigue
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How to Get Back to Predictable, Reliable, Daily Energy

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Deep Dive Medical Video on Chronic Fatigue:

Quiz Revealing Source(s) of Your Chronic Fatigue
Section 1 - Mitochondrial Breakdown (Energy Production)
Section 2 - HPA Axis Dysregulation (Stress Response)
Section 3 - Dysbiosis & Leaky Gut
Section 4 - Nutrient Deficiency
Section 5 - Toxic Burden
Section 6 - Infection & Immune Challenges
Section 7 - Sleep & Circadian Rhythm Disruption
Section 8 - Methylation Imbalance
Section 9 - Low-Grade Inflammation
Section 10 - Neurotransmitter Imbalance
Section 11 - Neuroinflammation
Section 12 - Autonomic Nervous System Imbalance (Dysautonomia)
Section 13 - Oral Infection / Dental Contributors
1. Mitochondrial Breakdown:
2. HPA Axis Dysregulation:
3. Dysbiosis & Leaky Gut:
4. Nutrient Deficiency:
5. Toxic Burden:
6. Infection & Immune Challenges:
7. Sleep & Circadian Rhythm Disruption:
8. Methylation Imbalance:
9. Low-Grade Inflammation:
10. Neurotransmitter Imbalance:
11. Neuroinflammation:
12. Autonomic Nervous System Imbalance:
13. Oral Infection / Dental Contributors:
5 Archetypical Profiles of Chronic Fatigue
The Wired Sleeper
Description:
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HPA axis dysregulation + cortisol collapse.
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Stuck in a loop of core exhaustion and insomnia.
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Feels “tired and wired” – unable to rest and constantly fatigued
Traits:
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Difficulty falling asleep despite exhaustion
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Morning fatigue, afternoon crashes, nighttime alertness
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Often misdiagnosed as anxiety or depression

The Foggy Thinker
Description:
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Mitochondrial collapse + neuroinflammation
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Struggles with memory, focus, and motivation
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Feels like their brain is wrapped in cotton
Traits:
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Brain fog, poor recall, slow processing
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Fatigue worsens with exertion or stress
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Often dismissed as "burnout" or "getting older"

The Detox Blocker
Description:
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Mycotoxin overload + sluggish detox pathways
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Sensitive to smells, chemicals, and environments
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Feels like their body is holding onto invisible toxins
Traits:
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Fatigue, headaches, chemical sensitivity
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Poor recovery and emotional flatness
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Often told "it's all in your head"

The Gut-Derailed Reactor
Description:
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Dysbiosis + malabsorption
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Experiences bloating, food sensitivities, and post-meal crashes
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Feels like their gut is sabotaging their energy
Traits:
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Fatigue after meals or infections
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Brain fog, mood swings, and digestive discomfort
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Often misdiagnosed as IBS or psychosomatic

The Nutrient Starved Achiever
Description:
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Micronutrient depletion + poor absorption
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Eats well, supplements often, but still feels depleted
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Feels like their cells are starving despite effort
Traits:
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Fatigue, poor focus, muscle cramps
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Symptoms worsen with stress or fasting
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Often told "labs are normal"
